Min-Xin Guan Selected Research

Leber Hereditary Optic Atrophy (Leber's Hereditary Optic Neuropathy)

1/2022	Mitochondrial tRNA variants in 811 Chinese probands with Leber's hereditary optic neuropathy.
1/2022	Leber's hereditary optic neuropathy-associated ND6 14484T > C mutation caused pleiotropic effects on the complex I, RNA homeostasis, apoptosis and mitophagy.
1/2021	Leber's Hereditary Optic Neuropathy Arising From the Synergy Between ND1 3635G>A Mutation and Mitochondrial YARS2 Mutations.
1/2021	Mechanistic insights into mitochondrial tRNAAla 3'-end metabolism deficiency.
1/2020	PRICKLE3 linked to ATPase biogenesis manifested Leber's hereditary optic neuropathy.
1/2020	Complex I mutations synergize to worsen the phenotypic expression of Leber's hereditary optic neuropathy.
1/2019	Contribution of mitochondrial ND1 3394T>C mutation to the phenotypic manifestation of Leber's hereditary optic neuropathy.
1/2018	Leber's hereditary optic neuropathy (LHON)-associated ND5 12338T > C mutation altered the assembly and function of complex I, apoptosis and mitophagy.
1/2018	Leber's hereditary optic neuropathy caused by a mutation in mitochondrial tRNAThr in eight Chinese pedigrees.
12/2017	Leber's hereditary optic neuropathy is potentially associated with a novel m.5587T>C mutation in two pedigrees.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Min-Xin Guan Research Topics

Disease

56	Deafness (Deaf Mutism) 10/2022 - 07/2002
51	Hearing Loss (Hearing Impairment) 10/2022 - 01/2004
40	Mitochondrial Diseases (Mitochondrial Disease) 10/2022 - 02/2006
25	Nonsyndromic Deafness 01/2017 - 01/2004
20	Leber Hereditary Optic Atrophy (Leber's Hereditary Optic Neuropathy) 01/2022 - 03/2005
12	Sensorineural Hearing Loss 12/2020 - 01/2004
11	Hypertension (High Blood Pressure) 11/2019 - 03/2008
11	Ototoxicity 03/2017 - 01/2004
5	Optic Nerve Diseases (Optic Neuropathy) 01/2022 - 04/2010
5	Vision Disorders (Hemeralopia) 12/2017 - 11/2009
5	Essential Hypertension 08/2012 - 08/2009
4	Aminoglycoside-Induced Deafness 01/2011 - 01/2004
3	Eye Diseases (Eye Disease) 01/2022 - 04/2011
3	Neoplasms (Cancer) 11/2020 - 08/2005
3	Bilateral Hearing Loss 10/2007 - 05/2007
2	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 01/2021 - 01/2019
2	Optic Atrophy 12/2017 - 01/2016
2	Lactic Acidosis 01/2017 - 05/2010
2	Mitochondrial Encephalomyopathies (Mitochondrial Encephalomyopathy) 01/2017 - 05/2010
2	Stroke (Strokes) 01/2017 - 05/2010
2	Diabetes Mellitus 03/2015 - 09/2006
2	Coronary Disease (Coronary Heart Disease) 01/2014 - 10/2013
2	Cardiovascular Diseases (Cardiovascular Disease) 06/2009 - 03/2008
1	Kidney Diseases (Kidney Disease) 01/2022
1	Cysts 01/2022
1	Hematuria 01/2022
1	Chronic Renal Insufficiency 01/2022
1	Proteinuria 01/2022
1	Hyperuricemia 01/2022
1	Endometriosis 01/2021
1	Inflammation (Inflammations) 01/2021
1	Insulin Resistance 01/2021
1	Nonsyndromic sensorineural hearing loss 12/2020
1	Diabetes Complications 12/2019
1	Coronary Artery Disease (Coronary Atherosclerosis) 01/2019
1	Breast Neoplasms (Breast Cancer) 01/2019
1	Gram-Negative Bacterial Infections 03/2017

Drug/Important Bio-Agent (IBA)

62	Mitochondrial DNA (mtDNA)IBA 01/2022 - 01/2004
42	12S ribosomal RNAIBA 10/2022 - 11/2002
40	Transfer RNA (tRNA)IBA 10/2022 - 07/2002
39	AminoglycosidesIBA 01/2018 - 07/2002
16	Ser Transfer RNAIBA 11/2020 - 01/2004
9	NucleotidesIBA 01/2020 - 06/2010
7	Glu Transfer RNAIBA 01/2021 - 10/2006
6	Leu Transfer RNAIBA 01/2021 - 09/2006
6	Ala Transfer RNAIBA 01/2021 - 01/2004
6	Ile Transfer RNAIBA 01/2021 - 03/2008
6	Proteins (Proteins, Gene)FDA Link 01/2019 - 08/2005
5	Met Transfer RNAIBA 11/2019 - 08/2009
5	Thr Transfer RNAIBA 01/2019 - 10/2006
5	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2017 - 02/2012
5	Anti-Bacterial Agents (Antibiotics)IBA 03/2013 - 05/2006
4	Gln Transfer RNAIBA 01/2021 - 08/2009
3	Adenosine (Adenocard)FDA LinkGeneric 01/2021 - 01/2018
3	Tyrosine-tRNA LigaseIBA 01/2021 - 02/2016
3	His Transfer RNAIBA 01/2020 - 10/2011
2	Phe Transfer RNAIBA 01/2022 - 01/2017
2	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2021 - 04/2009
2	RNA (Ribonucleic Acid)IBA 01/2021 - 11/2009
2	AnticodonIBA 01/2021 - 01/2018
2	Asp Transfer RNAIBA 11/2020 - 12/2016
2	Adenosine Triphosphate (ATP)IBA 01/2018 - 12/2017
2	DNA (Deoxyribonucleic Acid)IBA 12/2017 - 11/2013
2	Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)IBA 01/2017 - 05/2010
2	RNA Precursors (Precursor, mRNA)IBA 09/2008 - 10/2005
2	Pharmaceutical PreparationsIBA 10/2005 - 01/2004
1	immune RNA (I-RNA)IBA 01/2022
1	Therapeutic UsesIBA 01/2021
1	Trp Transfer RNA (tRNA(Trp))IBA 01/2021
1	GuanineIBA 01/2021
1	LipidsIBA 01/2021
1	Lys Transfer RNAIBA 01/2021
1	ResveratrolIBA 01/2021
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2021
1	microtubule-associated protein 1B (MAP5)IBA 12/2020
1	PhosphoproteinsIBA 12/2020
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 12/2020
1	LigandsIBA 11/2020
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 11/2020
1	Adenosine Triphosphatases (ATPase)IBA 01/2020
1	Histidine-tRNA LigaseIBA 01/2020
1	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 12/2019
1	Folic Acid (Vitamin M)FDA LinkGeneric 12/2019
1	Messenger RNA (mRNA)IBA 11/2019
1	shikoninIBA 01/2019
1	pevonedistatIBA 01/2019
1	Metformin (Glucophage)FDA LinkGeneric 01/2019
1	Electron Transport Complex I (NADH-CoQ Reductase)IBA 01/2019
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2019
1	Superoxides (Superoxide)IBA 01/2018
1	Codon (Codons)IBA 01/2018
1	Adenine FDA LinkGeneric 01/2018
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 12/2017
1	Oxidoreductases (Dehydrogenase)IBA 12/2017
1	NADP (NADPH)IBA 12/2017
1	FlavoproteinsIBA 12/2017
1	Ferredoxins (Ferredoxin)IBA 12/2017
1	Ferredoxin-NADP Reductase (Adrenodoxin Reductase)IBA 12/2017
1	Cytochromes b (Cytochrome b)IBA 12/2017

Therapy/Procedure

8	Therapeutics 10/2022 - 08/2005